1. Immunosuppressant drugs and renal transplant: Practical considerations for the use of tacrolimus

    Renal transplant patient care poses challenges such as maintaining a reasonable balance between efficacy and toxicity of immunosuppression. Different regimens of immune-suppressants are available and are determined by local protocols, aiming to address different levels of immunological risk. Owing to the narrow therapeutic index and large intra- and interpatient variability, drug monitoring of especially the calcineurin agents, continues to play an important role in the management of these patients.

  2. Coeliac disease

    Gluten related disorders can be classified according to pathogenesis: Autoimmune disease (Coeliac disease, dermatitis herpetiformis, gluten ataxia), non autoimmune disease (related to gluten sensitivity) and allergic disease (wheat allergy).

  3. Whooping Cough Bordetella pertussis: Resurgence of an Old Disease - Facts in 2016

    Whooping cough is an acute, highly contagious respiratory disease with a significant incidence of mortality in children under 5 years of age. Certain dogmas previously held concerning the disease incidence, clinical presentation, diagnosis and prevention need to be revisited as new concepts concerning the disease now hold true.

  4. Evolution and the molecular basis of psychiatric illness

    Uncovering the molecular pathology and biochemistry of mental health disease is currently one of the major challenges of modern medicine. For the primary psychotic, mood and anxiety disorders there are no diagnostic pathology tests, an understanding of the pathophysiology is often rudimentary and the molecular pathology largely unknown. There are many reasons for this but perhaps the most significant is that mental health illnesses do not lend themselves to enquiry in the same way as other disorders.